1190927-74-2

903129-71-5

1190927-74-2

The general procedure for the synthesis of 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride using 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine as starting material was as follows: 284 mg of 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine was dissolved in dichloromethane (DCM) , followed by the addition of 5.7 mL of 4 M hydrochloric acid in 1,4-dioxane solution. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the progress of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was concentrated and dried to give 250 mg of 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride as a beige solid powder in 93% yield.