1189477-66-4

Crystalline Solid

Labeled Nilutamide, intended for use as an internal standard for the quantification of Nilutamide by GC- or LC-mass spectrometry.

Nonsteroidal antiandrogen. Antineoplastic (hormonal)

Nilutamide-d₆ is intended for use as an internal standard for the quantification of nilutamide by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor. It reverses testosterone-induced increases in cell proliferation with an IC₅₀ value of 412 nM in mouse mammary carcinoma cells in vitro. It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg. Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.

Store at -20°C

[1] S M SINGH  F L  S Gauthier. Androgen receptor antagonists (antiandrogens): structure-activity relationships.[J]. Current medicinal chemistry, 2000, 7 2: 211-247. DOI: 10.2174/0929867003375371
[2] JACQUES SIMARD  Fernand L  Shankar Mohan Singh. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters[J]. Urology, 1997, 49 4: Pages 580-589. DOI: 10.1016/s0090-4295(97)00029-0
[3] A.E. WAKELING. Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens[J]. Journal of steroid biochemistry, 1981, 15: Pages 355-359. DOI: 10.1016/0022-4731(81)90297-1