1189477-66-4

Crystalline Solid

Labeled Nilutamide, intended for use as an internal standard for the quantification of Nilutamide by GC- or LC-mass spectrometry.

Nonsteroidal antiandrogen. Antineoplastic (hormonal)

Nilutamide-d₆ is intended for use as an internal standard for the quantification of nilutamide by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor. It reverses testosterone-induced increases in cell proliferation with an IC₅₀ value of 412 nM in mouse mammary carcinoma cells in vitro. It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg. Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.

Store at -20°C