Chemical Properties
| Sequence | H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH ?(Disulfide bridge Cys11-Cys27) |
Hazard Information
Uses
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].
in vivo
Ularitide (10?nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1].
| Animal Model: | Female dogs with or without surgically induced chronic aortocaval fistula[1] |
| Dosage: | 5 and 10 pmol/kg/min |
| Administration: | i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. |
| Result: | Increased in urine volume and sodium excretion with high-output CHF. |
References
[1] Anker SD, et al. Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
[2] Korn C, et al. Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin-induced permeability raise of human endothelial cell monolayers. Arzneimittelforschung. 1998 Mar;48(3):251-8. PMID:9553682
[3] Nally JE, et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide. Br J Pharmacol. 1995 Apr;114(7):1391-6. DOI:10.1111/j.1476-5381.1995.tb13360.x
[4] Valentin JP, et al. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr;21(4):432-8. DOI:10.1161/01.hyp.21.4.432
[5] Choi MR, et al. Urodilatin regulates renal dopamine metabolism. J Nephrol. 2013 Nov-Dec;26(6):1042-8. DOI:10.5301/jn.5000279
[2] Korn C, et al. Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin-induced permeability raise of human endothelial cell monolayers. Arzneimittelforschung. 1998 Mar;48(3):251-8. PMID:9553682
[3] Nally JE, et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide. Br J Pharmacol. 1995 Apr;114(7):1391-6. DOI:10.1111/j.1476-5381.1995.tb13360.x
[4] Valentin JP, et al. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr;21(4):432-8. DOI:10.1161/01.hyp.21.4.432
[5] Choi MR, et al. Urodilatin regulates renal dopamine metabolism. J Nephrol. 2013 Nov-Dec;26(6):1042-8. DOI:10.5301/jn.5000279
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