1186-30-7

Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate. Farnesylation is essential for the function of a number of proteins involved in signal transduction.

Dimethylallyl Pyrophosphate Triammonium Salt is a synthetic reagent in biochemical reactions. It is a natural occurring intermediate in biosynthetic pathways for the synthesis of natural products. Useful for the preparation of natural and unnatural terpenoid precursors of insect juvenile hormone.

Intermediate in terpene biosynthesis

[1] GRAHAM F. BARNARD  George P. Human liver prenyltransferase and its characterization[J]. Biochimica et Biophysica Acta (BBA) - Enzymology, 1981, 661 1: Pages 87-99. DOI: 10.1016/0005-2744(81)90086-3
[2] F. MARK LASKOVICS  C. D P. Prenyltransferase: determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments[J]. Biochemistry Biochemistry, 1981, 20 7: 1893-1901. DOI: 10.1021/bi00510a027
[3] RAYMOND J. HOHL. Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids[J]. Lipids, 1998, 33 1: 39-46. DOI: 10.1007/s11745-998-0178-x