Step 2: Synthesis of 6-bromo-2-methylpyridin-3-ol
4,6-Dibromo-2-methylpyridin-3-ol (15.8 g, 59.4 mmol) was dissolved in tetrahydrofuran (THF, 200 mL). The reaction solution was cooled to -78°C and n-butyllithium (n-BuLi, 50 mL, 125 mmol, 2.5 M hexane solution) was slowly added dropwise at this temperature. After the dropwise addition, the reaction temperature was maintained at -78°C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with deionized water (50 mL) and the reaction solution was neutralized with 2 N hydrochloric acid (HCl). Subsequently, the aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford 6-bromo-2-methylpyridin-3-ol (10.5 g, 95% yield) as a yellow oil. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 300 MHz, DMSO-d6): δ 2.29 (s, 3H), 7.08 (d, 1H), 7.26 (d, 1H), 10.08 (s, 1H).
