1166-01-4

Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM). Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels[1].

ChEBI: 3,5-diamino-N-[amino-[(3,4-dichlorophenyl)methylimino]methyl]-6-chloro-2-pyrazinecarboxamide is a member of pyrazines and a member of guanidines.

[1] Plasman P O, et al. Inhibition of Na/Ca exchange in pancreatic islet cells by 3′, 4′-dichlorobenzamil[J]. Biochemical pharmacology, 1991, 41(11): 1759-1768. DOI:10.1016/0006-2952(91)90181-4