CM-10-18 is a potent ER α-glucosidase inhibitor. CM-10-18 efficiently protected the lethality of dengue virus infection of mice. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever.
Uses
CM-10-18 is a potent and orally active inhibitor of both α-glucosidases I and II in vitro and in treated animals. CM-10-18 inhibits DENV infection of cultured human cells and reduces the peak viremia of DENV in mice[1].
References
[1] Chang J, et al. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res. 2011;89(1):26-34. DOI:10.1016/j.antiviral.2010.11.002
