115722-23-1

Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) binds to cell membranes through hydrophobic interactions and electrostatic attraction. Cardiotoxin Analog (CTX) IV (6-12) is mainly embedded in the lipid bilayer through the N-terminal hydrophobic loop (amino acid sequence at positions 6-12), destroying the stability of the membrane structure, inducing membrane lipid disorder and cell lysis, and exhibiting hemolysis and cytotoxicity[1][2].

[1] Kaneda N, et al. The amino acid sequence of cardiotoxin-analogue IV from the venom of Naja naja atra. FEBS Lett. 1976 Nov;70(1):217-22. DOI:10.1016/0014-5793(76)80761-2
[2] Dufourcq J, et al. Structure-function relationships for cardiotoxins interacting with phospholipids. Toxicon. 1982;20(1):165-74. DOI:10.1016/0041-0101(82)90187-8