ChemicalBook CAS DataBase List 115-46-8

115-46-8

Name	alpha,alpha-Diphenyl-4-piperidinomethanol
CAS	115-46-8
EINECS(EC#)	204-092-5
Molecular Formula	C18H21NO
MDL Number	MFCD00066980
Molecular Weight	267.37
MOL File	115-46-8.mol

Synonyms

2,2-DIPHENYL-4-PIPERIDONOMETHANOL 4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL A,A-DIPHENYL-4-PIPERIDINEMETHANOL ALPHA-(4-PIPERIDYL)BENZHYDROL ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL AZACYCLONAL AZACYCLONOL DIPHENYL-4-PIPERIDINEMETHANOL DIPHENYL-PIPERIDIN-4-YL-METHANOL gamma-pipradol TIMTEC-BB SBB003057 4-Piperidinemethanol, alpha,alpha-diphenyl- alpha,alpha-diphenyl-4-piperidinemethano Ataractan Azacyklonol Calmeran Diphenyl(4-piperidinyl)methanol Diphenyl-4-piperidylmethanol Frenoton

Chemical Properties

Appearance	white to light beige crystalline powder
Melting point	160-163 °C
Boiling point	410.55°C (rough estimate)
density	1.0449 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5100 (estimate)
storage temp.	Store below +30°C.
solubility	Chloroform, Methanol (Slightly, Sonicated)
form	Solid
pka	13.32±0.29(Predicted)
color	White to light beige
InChI	InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
InChIKey	ZMISODWVFHHWNR-UHFFFAOYSA-N
SMILES	C(O)(C1CCNCC1)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference	115-46-8(CAS DataBase Reference)
NIST Chemistry Reference	Azacyclonol(115-46-8)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319
Precautionary statements	P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S24/25:Avoid contact with skin and eyes . less more
WGK Germany	WGK 3 highly water endangering
RTECS	TN0470000
REACH Registrations	Active
HS Code	29333999
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2

Raw materials And Preparation Products

Hazard Information

Description

alpha,alpha-Diphenyl-4-piperidinomethanol(115-46-8) is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.

Chemical Properties

white to light beige crystalline powder

Originator

Frenquel,Merrell,US,1955

Uses

Anxiolytic;H1 antagonist

Uses

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490).

Definition

ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.

Manufacturing Process

A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.

Brand name

Frenquel (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

storage

Store at -20°C

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Shanghai Taijilin Industrial Co., Ltd.

Telephone02150630626 17717886015

Websitehttp://www.tajilin.com/

Jiangxi Bairui Technology Co., Ltd

Telephone13026208279 13026208279

Website

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Energy Chemical

Telephone 400-0056266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

shanghai science Bio-Pharmceutical.co,ltd.

Telephone021-021-57872719 13761402923

Websitehttp://www.freefluor.com

Adamas Reagent, Ltd.

Telephone400-6009262 15618770481

Websitehttp://www.tansoole.com

Accela ChemBio Co.,Ltd.

Telephone021-50795510 4000665055

Websitehttp://www.shao-yuan.com/

Shanghai Longsheng chemical Co.,Ltd.

Telephone58099637 13585536065

Websitehttp://www.shlshg.com

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone15527621225; 15527621225

Websitehttp://www.farchem.com/

Syntechem Co.,Ltd

Telephone

Websitehttp://www.syntechem.com/

Zhejiang Qiming Pharmaceutical Co., Ltd.

Telephone+86-571-87163895 +86-571-87163893

Websitehttp://www.qimingpharm.com/

Aemon Chemical

Telephone0086-755-86198205

Websitehttp://www.aemonchem.com

1of4

Related Products

Send Inquriy