1147271-25-7

Name	2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
CAS	1147271-25-7
Molecular Formula	C23H22N4O3
MDL Number	MFCD18800878
Molecular Weight	402.446
MOL File	1147271-25-7.mol

Synonyms

2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one 5H-Indeno[1,2-d]pyrimidin-5-one, 2-amino-8-[2-(4-morpholinyl)ethoxy]-4-phenyl-

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Hazard Information

Description

JNJ-40255293 is an adenosine A2A/A1 antagonist with efficacy in preclinical models of parkinson's disease.

Uses

JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].

in vivo

JNJ-40255293 (0.1-10 mg/kg, p.o.) can reverse haloperidol (HY-14538)-induced catalepsy in male Balb/c mice. In male Wistar rats, JNJ-40255293 also dose-dependently reversed haloperidol (0.63 mg/kg, subcutaneous injection)-induced catalepsy, enhanced active arousal, and significantly reversed reserpine (HY-N0480 ) caused deficits in motor activity^[1].

References

[1] John R Atack, et al. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19. DOI:10.1021/cn5001606

Supplier

Shanghai Ennopharm Co., Ltd.

Telephone+86 (21) 6435-5022

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm

shanghai cooperpharm co.,LTD .

Telephone+86-021-58975553

Websitehttp://www.cooperpharm.com

Changzhou Chenhong Biotechnology Co., Ltd.

Telephone+86-0519-85788828 +86-13775037613

Websitehttp://www.chemrenblock.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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