114414-17-4

16867-03-1

114414-17-4

General procedure for the synthesis of 2-amino-4-bromopyridin-3-ol hydrobromide from 2-amino-3-hydroxypyridine: Bromine (11.2 mL, 0.21 mol) was slowly added dropwise to a mechanically stirred suspension of 2-amino-3-hydroxypyridine (20 g, 0.18 mol) in acetic acid (300 mL) at 5-10 °C, after which the reaction system was brought to room temperature. The reaction mixture was heated to 120-125 °C, maintained for 12 h and then concentrated to give the crude product. The crude product was ground with ether (50 mL x 3) and subsequently dried under vacuum to afford 2-amino-4-bromopyridin-3-ol hydrobromide as a dark brown solid, which could be used in subsequent reactions without further purification. Yield: 48.5 g; MS (m/z): 189.3, 191.1 ([M + H]+).