113614-08-7

Beflubutamid is an antiparasitic agent, a herbicide.

ChEBI: N-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butanamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 2-[4-fluoro-3-(trifluoromethyl)phenoxy]butyric acid with the amino group of benzylamine. It is a monocarboxylic acid amide, an aromatic ether, a member of monofluorobenzenes and a member of (trifluoromethyl)benzenes. It is functionally related to a benzylamine.

Under alkaline conditions, 4-fluoro-3-trifluoromethylphenol and ethyl 2-bromobutyrate undergo an O-alkylation reaction in an organic solvent, followed by reflux to give the intermediate ethyl 2-[4-fluoro-3-(trifluoromethyl)phenoxy]butyrate. This ester intermediate is reacted with benzylamine in toluene in the presence of sodium methoxide. After reflux, washing, concentration, and recrystallization (e.g., recrystallization with ethanol), Beflubutamid is obtained.