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Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner. It acts by displaying significant repression of Shh-induced Gli1/Gli2.

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

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[1] Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem DOI:10.3389/fchem.2017.00076
[2] Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. DOI:10.1038/nchembio.142
[3] Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504. DOI:10.1242/bio.20134275
[4] Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781. DOI:10.1080/10428194.2018.1493727