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Questions And Answer

• Anion exchange resin

  Cholestyramine, is a strongly basic quaternary ammonium anion exchange resin, it is used in low-density lipoprotein hyperlipidemia that includesⅡa, Ⅱb hyperlipidemia,it is the strongest cholesterol-lowering drug . After oral administration , it is not absorbed ,in the intestine the containing chlorine ion is exchanged with the bile acid,it can bind stably with bile acids until the feces, it can reduce the absorption of exogenous cholesterol, hinder the enterohepatic circulation of bile acids absorbed into blood ,it can reduce the amount of bile acids in the blood , which prompt blood cholesterol conversion to bile acids, which lowers cholesterol. Cholestyramine has no lowering effect on triglycerides. Because of the powerful cholesterol-lowering effect, the product becomes the choice of drug for type Ⅱa hyperlipoproteinemia. It shall be used in combination with drugs which can reduce blood triglyceride such as clofibrate or nicotinic acid for the treatment of type Ⅱb hyperlipoproteinemia .For hyperlipoproteinemia Ⅲ, Ⅳ, Ⅴ , we should not use cholestyramine. In addition, the product can also be used for the treatment of skin itching caused by atherosclerosis and cirrhosis, cholelithiasis .
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• Indications

  Cholestyramine: it is mainly used for the treatment of type Ⅱa hyperlipoproteinemia, especially in familial hypercholesterolemia.
  Also it is used for the treatment of primary biliary cirrhosis, drug-induced cholestatic jaundice itching, hypercholesterolemia, chronic cholecystitis, gallstones,Porphyrin thesaurismosis .
  Treatment of Atherosclerosis: 4~5g, 3 times/d. Itching: Start amount of 6~10g/d, maintenance dose of 3g/d,administration for 3 times .
  Long-term use can reduce intestinal binding bile salt ,and cause fat malabsorption, long-term use should add vitamin A, D, K and other fat-soluble vitamins and calcium appropriately , gastrointestinal responders may be appropriate with stomach medication.
  The above information is edited by the chemicalbook of Tian Ye.;

• Adverse reactions and precautions

  1. Start taking can cause nausea, bloating, diarrhea, constipation and other gastrointestinal side effects, which may disappear when continuing taking . It should be discontinued, if constipation is too long, individual patients can suffer intestinal obstruction.
  2. The product is dry powder, and the smell is unpleasant , so it needs to be taken by mixing thoroughly with water and flavors.
  3. Long-term large doses, since it can affect the absorption of fat and fat-soluble vitamins, vitamin A, D, K and calcium should be added appropriately .
  4. Long-term use of cholestyramine can cause folic acid deficiency, especially in children, so it is necessary to add folic acid daily 5mg.
  5. Cholestyramine can combine with cardiac glycosides, double coumarin anticoagulant drugs, hydrochlorothiazide, phenobarbital, thyroxine, phenylbutazone, warfarin and other drugs, which hinders the absorption of these drugs, when it is taken with these drugs ,it needs a certain time interval. ;

• Uses

  Lipid-lowering drugs for type Ⅱ hyperlipidemia, atherosclerosis and other diseases. ;

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