1100750-16-0

1100750-13-7

1100750-16-0

6-Methoxy-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (3.8 g) was used as starting material and dissolved in an aqueous solution. Subsequently, 48% hydrobromic acid (HBr) solution (1.4 mL) was slowly added. The reaction mixture was stirred continuously at 100 °C for 72 hours. Upon completion of the reaction, the mixture was concentrated to remove the solvent. Finally, the residue was purified by preparative high performance liquid chromatography (HPLC) to afford the target product 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ol (3.6 g).