ChemicalBook CAS DataBase List 1098-97-1

1098-97-1

Name	PYRITHIOXIN
CAS	1098-97-1
EINECS(EC#)	214-150-1
Molecular Formula	C16H20N2O4S2
MDL Number	MFCD00151477
Molecular Weight	368.47
MOL File	1098-97-1.mol

Synonyms

5-[[5-HYDROXY-4-(HYDROXYMETHYL)-6-METHYL-PYRIDIN-3-YL]METHYLDISULFANYLMETHYL]-4-(HYDROXYMETHYL)-2-METHYL-PYRIDIN-3-OL PYRITHIOXIN PYRITHIOXINE PYRITINOL 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethano 3,3’-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol) 3,3’-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethano biocefalin bonol dipyridoxolyldisulfide encefabol epocan pyridoxine-5-disulfide pyridoxinedisulfide vitaminb6disulfide bis(5-hydroxy-4-hydroxymethyl-6-methyl-3-pyridylmethyl) disulphide pyrithioxin free base Bis-[(3-Hydroxy-4-Hydroxymethyl-2-Methyl-5-Pyridyl)-Methyl]-Disulfide PYRITINOL (PYRITHIOXINE) BASE PYRITINOL (PYRITHIOXINE) HCL

Chemical Properties

Melting point	218-220°
Boiling point	742.8±60.0 °C(Predicted)
density	1.448±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in DMSO
form	neat
pka	9.31±0.10(Predicted)
color	White to Light yellow to Light orange
Merck	14,7996
InChI	InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3
InChIKey	SIXLXDIJGIWWFU-UHFFFAOYSA-N
SMILES	S(CC1=C(CO)C(O)=C(C)N=C1)SCC1=C(CO)C(O)=C(C)N=C1
CAS DataBase Reference	1098-97-1(CAS DataBase Reference)

Safety Data

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H315-H318-H335
Precautionary statements	P261-P280-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	26 less more
WGK Germany	2
RTECS	UT4836666
HS Code	2936.25.0000

Hazard Information

Description

Pyritinol, the disulfide of pyridoxine-5-thiol, is marketed as a cerebral stimulant in Europe. Both the thiol and the disulfide have been shown to have d-penicillamine-like activity in the treatment of rheumatoid arthritis. Adverse effects are similar to those seen with d-penicillamine. Occasionally, pyritinol seems effective and better tolerated in some individuals who fail to respond to d-penicillamine.

Uses

cognition enhancer, nootropic

Uses

Pyritinol can be used as a nootropic used in the prevention and treatment of cerebrovascular diseases.

Definition

ChEBI: Pyritinol is a member of methylpyridines.

Brand name

Biontabol;Bonifwn;Cefalogen;Cerebrotrofina;Cervitalin;Divalvon-d;Enbol;Encefort;Encerbrovit;Encerebron;Fulneurina;Geribolina;Gerontabol comp.;Juniormen;Leonar;Logos;Maind;Musa;Neuroxin;Piriditol;Piririomin;Piritinol;Piritiomin;Plenumil;Sawaxin;Scintidin;Tibased;Tomevit;Tonobrein;Tonomentis.

World Health Organization (WHO)

Pyritinol, which is claimed to promote the uptake of glucose in the brain, is used in the treatment of cerebrovascular disorders. However, WHO is not aware of controlled experimental data to show that it has any therapeutic effect.

Synthesis

Synthesis: treatment of pyridoxine with hydrobromic acid gives 4,5-bis(bromomethyl)-3- hydroxy-2-methylpyridinium bromide, which when treated in the cold with potassium ethyl xanthate gives ethyl 4-hydroxymethyl- 3-hydroxy-2-methyl-3-pyridyl methylxanthate. Hydrolysis and oxidation are carried out in aqueous-alcoholic ammonia to give the disulfide pyritinol.
PYRITHIOXIN synthesis

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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