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1-(4-Amino-3-methoxyphenyl)-N,N-dimethyl-4-piperidinamine is a useful reagent for organic synthesis.

General procedure for the synthesis of 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine from BRIGATINIB intermediates: 4.09 g of Compound 29 was added to a reaction flask and dissolved with 40 mL of methanol. Subsequently, 0.4 g of 10% Pd/C catalyst (based on 10% of the mass of Compound 29) was added for the hydrogenation reduction reaction. The progress of the reaction was monitored by TLC and the reaction was complete after about 6 hours. After stopping the reaction, the reaction mixture was filtered and the catalyst was washed with a small amount of methanol. The filtrate was concentrated by distillation under reduced pressure to give 3.38 g of brown solid product 7-6 in 92.60% yield.

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