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16-Oxokahweol is a synthetic diterpene and derivative of kahweol . It increases cytosolic glutathione S-transferase (GST) activity and acid-soluble sulfhydryl levels in mouse liver and small bowel mucosa when administered at a dose of 10 μmol/animal once per day for three days.

16-Oxokahweol, a Kahweol (HY-N6258) derivative, is a glutathione S-transferase inducer[1].

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[1] L K Lam, et al. Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice. J Med Chem. 1987 Aug;30(8):1399-403. DOI:10.1021/jm00391a022