1086398-04-0

2,5-Diazaspiro[3.4]octane-5-carboxylicacid-1,1-dimethylethylester is a heterocyclic organic compound frequently used as a pharmaceutical intermediate. A few examples of 2,5-diazaspiro[3.4]octanes with N-Boc-protected azetidine nitrogen were obtained by condensation of N-Boc-azetidine-3-one with N-benzylbut-3-yn-1-amine elaborated for a streamlined synthesis of C(sp3)-rich N-heterospirocycles via visible-light-mediated Ir-photocatalyzed reactions^[1].

[1] Flodén, N.J.; Trowbridge, A.; Willcox, D.; Walton, S.M.; Kim, Y.; Gaunt, M.J. Streamlined Synthesis of C-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis. J. Am. Chem. Soc. 2019, 141, 8426–8430. DOI:10.1021/jacs.9b03372