108130-10-5

62774-90-7

75-03-6

108130-10-5

2,6-Dichloro-4-methylpyridine-3-carboxylic acid (100 g, 485 mmol) and potassium carbonate (100 g, 728 mmol) were stirred in dimethylformamide (1.25 L) for 30 hours at room temperature. Subsequently, ethyl iodide (59.5 mL, 728 mmol) was added to the reaction system and stirring was continued for 18 hours. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate (3×). The organic layers were combined, washed sequentially with water (2×) and brine (1×), dried over magnesium sulfate, and the solvent was evaporated to dryness under reduced pressure to afford ethyl 2,6-dichloro-4-methylpyridine-3-carboxylate (112 g), which was used for subsequent reactions without further purification.