CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].
References
[1] Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25. DOI:10.1038/s41589-024-01586-5
