1076225-27-8

PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t_1/2=4 min, C_Lint=350 (μL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h^[1].