1065124-65-3

Epsilon-momfluorothrin is a type I synthetic pyrethroid insecticide, activates constitutive androstane receptor (CAR), and induces hepatocellular tumors in rats[1].

ChEBI: Epsilon-momfluorothrin is a carboxylic ester obtained by formal condensation between the carboxy group of (1R,3R)-3-[(1Z)-2-cyanoprop-1-en-1-yl]-2,2-dimethylcyclopropane-1-carboxylic acid with the benzylic hydroxy group of [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methanol. It has a role as a pyrethroid ester insecticide and an agrochemical. It is a carboxylic ester, a member of cyclopropanes, an ether, an organofluorine insecticide, a tetrafluorobenzene and a nitrile. It is functionally related to a chrysanthemic acid.

Epsilon-momfluorothrin is synthesised commercially through a multi-step chemical process involving the esterification of a cyclopropane carboxylic acid derivative with a fluorinated benzyl alcohol

Axonic poison; keeps sodium channels in the neuronal membranes open, leading to hyperexcitation and paralysis.

[1] Okuda Y, et al. Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicol Sci. 2017 Aug 1;158(2):412-430. DOI:10.1093/toxsci/kfx102

Insecticide