1060808-94-7

670253-38-0

1060808-94-7

General procedure for the synthesis of 4-chloro-6-aminonicotinic acid from 6-amino-4-chloronicotinonitrile: Concentrated sulfuric acid (98%, 0.5 mL) was slowly added dropwise to a stirring suspension of 6-amino-4-chloronicotinonitrile (0.020 g, 0.130 mmol) in water (1 mL). The reaction mixture was heated to 100 °C and maintained for 18 hours. Upon completion of the reaction, it was cooled to room temperature and slowly added dropwise to a saturated sodium bicarbonate solution (2 mL) containing ice and the pH was adjusted to about 2. The resulting precipitate was collected by filtration, washed with water (2 mL), and subsequently air-dried to yield 4-chloro-6-aminonicotinic acid (0.019 g, 0.110 mmol, 84% yield) as a colorless powder, [M + H]+ m/z = 173.0.