ChemicalBook CAS DataBase List 105925-39-1

105925-39-1

Name	Tubulin inhibitor 6
CAS	105925-39-1
Molecular Formula	C20H14ClNO2S
Molecular Weight	367.85
MOL File	105925-39-1.mol

Chemical Properties

Melting point	155-157 °C
Boiling point	549.1±50.0 °C(Predicted)
density	1.364±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 62.5 mg/mL (169.91 mM)
form	A crystalline solid
pka	-5.56±0.20(Predicted)
color	White to off-white

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319-H335-H315
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

Hazard Information

Uses

Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].

Biological Activity

Tubulin inhibitor 6 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and efficiently kills malignant cells.

in vitro

Tubulin inhibitor 6 displays submicromolar antiproliferative activity.

target

storage

Store at -20°C

References

[1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t

Spectrum Detail

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Target	Value
PP2A ()