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Hazard Information

Questions And Answer

• Usage

  An oxidant in solid rocket propellants, ordnance, fireworks, airbag deployment systems, and commercial fertilizers.Perchlorates are also detected in consumer products such as bleach and sealing gaskets for food containers.;

• Clinical implications

  There are some mutations in the NIS gene (SLC5A5) that cause hypothyroidism and thyroid dyshormonogenesis. Anti-NIS antibodies have been found in thyroid autoimmune diseases. Defects of the pendrin gene (PDS, SLC26A4) result in Pendred Syndrome associated with profound sensorineural hearing loss and a thyroid condition called goiter.;

• Origins of environmental perchlorates

  Natural and anthropogenic sources. Five perchlorates are manufactured in large amounts as magnesium, potassium, ammonium, sodium, and lithium salts.;

• Exposure routes

  From food (especially leafy green vegetable and milk) or drinking water, but not through the skin. For fetuses and infants, from the placenta, breast milk (or cow milk), infant formula, and baby food. The level in urine for children of 0.5–6 years of age is 2–3 times higher than for children 10 or older.;

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