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5HPP-33 is a compound that was initially identified for its anti-angiogenic properties. It suppresses microtubule dynamics and depolymerises microtubule network by binding at vinblastine site on tubulin. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.

5HPP-33 is a thalidomide derivative with cell-proliferation inhibitory properties.

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).