105108-59-6

m-PEG3-4-nitrophenyl carbonate is a PEG linker with a nitrophenyl carbonate moiety. NPC is reactive towards the amino group of lysine by means of stable urethane linkages. The hydrophilic PEG linker increases the water solubility of the compound.

m-PEG2-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005