ChemicalBook CAS DataBase List 1050656-06-8

1050656-06-8

Name	Benzoic acid, 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]-
CAS	1050656-06-8
Molecular Formula	C27H21F3N2O3
Molecular Weight	478.46
MOL File	1050656-06-8.mol

Chemical Properties

Boiling point	711.4±60.0 °C(Predicted)
density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: soluble
form	A solid
pka	4.35±0.10(Predicted)
color	Off-white to gray

Hazard Information

Uses

MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. MF-766 behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. MF-766 can be used for cancer and inflammation diseases research[1][2].

in vivo

MF-766 (oral gavage; 30 mg/kg; once daily; 21 days) exhibits TGI% of 49% in CT26 tumor model. But it does not exhibits significant difference in EMT6 and 4T1 tumor model^[2].MF-766 (oral gavage; 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8) shows potent anti-tumor activities in different?? preclinical models. The % of TGI are 89%, 66% and 40%, respectively in CT26 tumor,? EMT6 and 4T1 tumor model^[2].

Animal Model:	Female C57BL/6?J strain mice injected subcutaneously with CT26, EMT6, or 4T1 cells^[2]
Dosage:	30 mg/kg combination with anti-PD-1 mDX400
Administration:	Oral gavage; 10 mg/kg or 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8
Result:	Improved anti-tumor activity in the setting of PD-1 blockade in multiple syngeneic models.

IC 50

EP4: 0.23 nM (Ki)

storage

Store at -20°C

References

[1] John Colucci, et al. Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain. Bioorg Med Chem Lett DOI:10.1016/j.bmcl.2010.04.065
[2] Yun Wang, et al. Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both DOI:10.1080/2162402X.2021.1896643

Spectrum Detail

Supplier

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070 13770331960

Websitehttp://www.echemlin.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 18916372613

Websitehttps://www.shyuanye.com

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Shanghai Dongyang Biotechnology Co., Ltd.

Telephone0512-13601744364 13601744364

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1201937/0_EN.htm

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Henan Alpha Chemical Co., Ltd.

Telephone0371-55013243 15324716602

Websitehttps://www.chemicalbook.com/supplier/24684125/

https://hanhongsci.com/

Telephone021-54306202 18917919676

Websitehttps://www.hanhongsci.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Telephone025-5885952 15955137747

Websitehttps://www.aikonchem.com/

HANGZHOU LEAP CHEM CO., LTD.

Telephone+86-571-87711850 +86-15355479329

Websitehttp://www.leapchem.com

1of3

Related Products

Send Inquriy