1043495-96-0

RO 5256390 is a trace amine-associated receptor 1(TAAR1) agonist which may be used as treatment of cocaine addiction.

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1)a GPCR primarily found in the brainexpressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophreniareduces cocaineμs reinforcng effectsand blocks binge-eating disorder.