1041026-70-3

Questions And Answer

• Preparation

  An empty flask was packed with 200 mg of 6-(1-phenyl-ethyl)-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester, ammonium formate (4.22 g, 67 mmol), 10% palladium/carbon (40 mg), and methanol (10 mL). The flask was filled with argon gas. The resulting mixture was stirred at 65°C for 3 hours. The mixture was filtered. The resulting mixture was concentrated under vacuum to give the title compound, TERT-BUTYL 2,6-DIAZASPIRO[3.3]HEPTANE-2-CARBOXYLATE.;

• 结构性质

  2,6-二氮杂螺[3.3]庚烷-2-甲酸叔丁酯从结构上看是氮杂环丁烷在C-3位与哌嗪的C-4位形成的螺环化合物，属［3+5］螺环化合物，结构相对简单，分子量小。;

• 用途

  2，6-二氮杂螺[3.3]庚烷-2-甲酸叔丁酯是含氮螺环化合物的一种，近年来已成为药物化学中药物发现时使用最频繁的分子砌块之一，受到制药公司和学术界的广泛关注。;

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