ChemicalBook CAS DataBase List 1038984-31-4

1038984-31-4

Name	CX-1632
CAS	1038984-31-4
Molecular Formula	C20H17FN4O3
MDL Number	MFCD31807599
Molecular Weight	380.37
MOL File	1038984-31-4.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO:21.67(Max Conc. mg/mL);56.97(Max Conc. mM)
form	Solid
color	Light yellow to yellow

Hazard Information

Uses

Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].

in vivo

Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) has anxiolytic-like and antidepressant-like effects in the CORT Mice Model^[2].
Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) reverts olfactory bulbectomy (OB)-induced hyperactivity and anxiety in bilateral olfactory bulbectomy mice model^[3].

Animal Model:	chronic corticosterone administration (CORT) mice^[2]
Dosage:	0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Reversed anxio-depressive phenotype in a neurogenesis-dependent task. Decreased the corticosterone-induced increase in emotionality. Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model. Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.

Animal Model:	bilateral olfactory bulbectomy mice model^[3]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Significantly reverted OB-induced hyperactivity after 28 days. Increased open field central activity in OB mice.

References

[1] Bretin S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors [J]. PLoS One, 2017, 12(9): e0184429.
[2] Mendez-David I, et al. S 47445 produces antidepressant-and anxiolytic-like effects through neurogenesis dependent and independent mechanisms [J]. Frontiers in pharmacology, 2017, 8: 462.
[3] Pilar-Cuellar F, et al. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice [J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, 93: 205-213.
[4] Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2018 Nov 14. pii: S1359-6446(18)30376-3. DOI:10.1016/j.drudis.2018.11.007

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