1038549-25-5

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK1 and ROCK2 with IC₅₀ values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.[Cayman Chemical]

[1] TINA MORWICK. Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase[J]. Journal of Medicinal Chemistry, 2009, 53 2: 759-777. DOI: 10.1021/jm9014263