Ono-RS 347 is an SRS-A antagonist. It is a new leukotriene antagonists.
Uses
ONO-RS-347 is an orally active and potent antagonist of leukotriene C4 and D4. ONO-RS-347 inhibits LTD4-induced bronchoconstriction in guinea pigs. ONO-RS-347 is promising for research of allergic asthma and other immediate hypersensitivty diseases[1].
References
[1] Nakai H, et al. New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships. J Med Chem. 1988 Jan;31(1):84-91. DOI:10.1021/jm00396a013
