1030203-81-6

HS 38 is a specific serine/threonine protein kinase inhibitor that affects the regulation of programmed cell-death and phosphorylation of smooth-muscle myelin.

HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinasealso called DAPK3) th at regulate programmed cell deathand also inhibits the closely related PIM3 kinase (IC50 = 200 nM76% inhibition at 10 RM). In addition to mediating apoptosisDAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscleand decreased contractile force generated in mouse aortarabbit ileumand calyculin A stimulated arterial muscle.