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Huangjiangsu A is a natural active ingredient found in many plants such as Dioscorea villosa and Polygonatum multiflorum. It belongs to the steroidal saponin class of compounds. Huangjiangsu A is not cytotoxic, and treatment of HepG2 cells with it prior to exposure to H2O2 was effective in increasing cell viability in a concentration-dependent manner. In addition, 50 μM of Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin increased GSH levels and reduced intracellular ROS production, thereby counteracting H2O2-induced injury. Thus, Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation, and is expected to be a potential drug for the treatment of liver diseases^[1-2].

Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. villosa. Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases[1].

[1] MAQSOOD A SIDDIQUI. Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells.[J]. Frontiers in Pharmacology, 2018. DOI:10.3389/fphar.2018.00797.
[2] LILI GVAZAVA . New furostanol glycosides from Polygonatum multiflorum (L.) All.[J]. Natural Product Research, 2019. DOI:10.1080/14786419.2018.1431628.