1024033-43-9

Since AZD 4017 has lower potency against the mouse enzyme, only a limited number of preclinical pharmacodynamic measurements are performed. Increasing the dose further led to a maximal effect of approximately 70% inhibition at 1500 mg/kg, equivalent to 10×IC₅₀ in the mouse, demonstrating the dose dependent inhibition of 11β-HSD1 by AZD 4017 in this model^[1].