1004517-48-9

A novel and effective difluorocarbene reagent for O-, S-, N-, C-difluoromethylation under mild conditions. When only 1.2 equivalent of the reagent is used, the difluoromethylated products can be obtained in moderate to excellent yields at low temperatures.

O-, S-, N-, C-difluoromethylation

[1] FEI WANG  Jinbo H  Weizhou Huang. Difluoromethylation of O-, S-, N-, C-Nucleophiles Using Difluoromethyltri(n-butyl)ammonium Chloride as a New Difluorocarbene Source[J]. Chinese Journal of Chemistry, 2011, 29 12: 2717-2721. DOI:10.1002/cjoc.201100325.