1002309-52-5

A dioxane (5 mL) solution of potassium acetate (270 mg, 2.67 mmol) and Pd(dppf)Cl2 (80 mg, 0.11 mmol) was added as 5-bromo-1-methylpyridin-2-one (200.0 mg, 1.06 mmol) and bis(pinacolato)diboron (410.0 mg, 1.61 mmol). The reaction mixture was microwaved at 100 °C for 2 hours. After completion of the reaction, the mixture was filtered, washed with water and extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product 1-methyl-6-oxo-1,6-dihydropyridine-3-boronic acid pinacol ester (59.0 mg, 23.6% yield). The product was detected by LCMS and the molecular ion peak (M + H)+ was 236.

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