100130-32-3

VUF8430 is a histamine H₄ receptor agonist (K_i = 31.6 nM). It is selective for histamine H₄ over H₁ and H₃ receptors in radioligand binding assays (K_is = >1 and 1 μM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H₂ receptors (pD₂ = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC₅₀ = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats. It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI).

VUF 8430 Dihydrobromide is an H4 receptor agonist.

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