1000577-78-5

217806-26-3

100-52-7

1000577-78-5

Tert-butyl azetidine-3-carbamate hydrochloride (200 mg, 0.96 mmol) and benzaldehyde (203 mg, 1.92 mmol) were added to triethylamine (0.133 mL, 0.96 mmol) and acetic acid (115 mg, 1.92 mmol) in methanol (10 mL), and the reaction was stirred for 30 min at 24 °C. Subsequently, sodium cyanoborohydride (181 mg, 2.88 mmol) was added to the reaction system. The reaction mixture was continued to be stirred at 24 °C for 12 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography to afford tert-butyl (1-benzylazetidin-3-yl)carbamate (120 mg, 48% yield).LCMS (m/z): 262.2 [M + H]+.