1-Deoxynojirimycin

Bezeichnung:1-Deoxynojirimycin

CAS-Nr19130-96-2

Englisch Name:1-Deoxynojirimycin

CBNumberCB9128150

SummenformelC6H13NO4

Molgewicht163.17

MOL-Datei19130-96-2.mol

1-Deoxynojirimycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	195-196°C
Siedepunkt	361.1±42.0 °C(Predicted)
Dichte	1.456±0.06 g/cm3(Predicted)
Dampfdruck	0Pa at 25℃
RTECS-Nr.	TN4350300
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Soluble in Water up to 25 mg/ml).
pka	13.77±0.70(Predicted)
Aggregatzustand	Powder
Farbe	White
Wasserlöslichkeit	Soluble in water, dimethyl sulfoxide and methanol.
BRN	3588039
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
LogP	-1.8
CAS Datenbank	19130-96-2(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	1
HS Code	29329990

Gefahreninformationscode (GHS)

1-Deoxynojirimycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Deoxynojirimycin (19130-96-2) inhibits α-glucosidase I and II.1,2 Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.3 May be used to produce an affinity ligand for purifying glucosidase 1.4 Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.5
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.
Verwenden
An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.
Verwenden
An inhibitor of α-glucosidase I and II
Definition
ChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Biologische Aktivität
Inhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM).
Lager
+4°C
Einzelnachweise
1) Fuhrmann et al. (1985), Inhibitors of oligosaccharide processing; Biochim. Biophys, Acta, 825 95 2) Hughs and Rudge (1994), Deoxynojirimycin: synthesis and biological activity; Nat. Prod. Rep., 11 135 3) Papandreou et al. (2002), The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step; Mol. Pharmacol., 61 186 4) Hettkamp et al. (1984), Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides; Eur. J. Biochem., 142 85 5) Suh et al. (1992), Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides; J. Biol. Chem., 267 21671

1-Deoxynojirimycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

19130-96-2, 1-Deoxynojirimycin Verwandte Suche:

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