(S)-β-Amino-1H-imidazol-4-propanoldihydrochlorid

Bezeichnung:(S)-β-Amino-1H-imidazol-4-propanoldihydrochlorid

CAS-Nr1596-64-1

Englisch Name:L-(-)-Histidinol dihydrochloride

CBNumberCB6666879

SummenformelC6H13Cl2N3O

Molgewicht214.09

MOL-Datei1596-64-1.mol

Synonyma

(S)-β-Amino-1H-imidazol-4-propanoldihydrochlorid

(S)-β-Amino-1H-imidazol-4-propanoldihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	198-201 °C (dec.)(lit.)
alpha	-3 º (C=2, H2O 24 ºC)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
Aggregatzustand	Crystalline Powder
Farbe	White to slightly beige
BRN	3914853
InChIKey	FRCAFNBBXRWXQA-XRIGFGBMSA-N
CAS Datenbank	1596-64-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36-37/39-36/37-22
WGK Germany	3
RTECS-Nr.	NI8260000
HS Code	29332900

Gefahreninformationscode (GHS)

L-(-)-Histidinol dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants. It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase. L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.
Chemische Eigenschaften
white to slightly beige crystalline powder
Verwenden
A metabolite within Histidine metabolism.
Definition
ChEBI: L-Histidinol dihydrochloride is an aralkylamine.
in vitro
preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1].
in vivo
l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1].
Einzelnachweise
[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30.

(S)-β-Amino-1H-imidazol-4-propanoldihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1596-64-1, L-(-)-Histidinol dihydrochloride Verwandte Suche:

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