4-Brommethyl-7-methoxycumarin

Bezeichnung:4-Brommethyl-7-methoxycumarin

CAS-Nr35231-44-8

Englisch Name:4-Bromomethyl-7-methoxycoumarin

CBNumberCB6345309

SummenformelC11H9BrO3

Molgewicht269.09

MOL-Datei35231-44-8.mol

Synonyma

4-Brommethyl-7-methoxycumarin

4-Brommethyl-7-methoxycumarin physikalisch-chemischer Eigenschaften

Schmelzpunkt	213-215 °C (lit.)
Siedepunkt	385.3±42.0 °C(Predicted)
Dichte	1.552±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	chloroform: soluble20mg/mL, clear, colorless to faintly yellow
Aggregatzustand	Powder and/or Chunks
Farbe	Off-white to light yellow or beige
Wasserlöslichkeit	insoluble
maximale Wellenlänge (λmax)	330 nm (MeOH)
BRN	187211
Stabilität	Stable, but moisture and light-sensitive. Combustible. Incompatible with strong oxidizing agents.
Major Application	Detection of nitrated explosives; measuring ultraviolet ray power; photoacid generators; polyurethane foams; photoresists silica nanoparticles
Biologische Anwendungen	Analyzing/detecting carboxylic acids;analyzing/labeling fatty acids; detecting nitric oxide; detecting/separating bile acids; labeling pyrimidine nucleobases; anticancer agents; biomedical trace analysis; herbicides; as a substrate for measuring histone acetyltransferases (HATs) activity, peptidases activity, sirtuin activity
LogP	2.730 (est)
CAS Datenbank	35231-44-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36-37/39
RIDADR	1759
WGK Germany	3
HazardClass	8
PackingGroup	III
HS Code	29322090

Gefahreninformationscode (GHS)

4-Bromomethyl-7-methoxycoumarin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Light Green-Yellow Crystals
Verwenden
4-Bromomethyl-7-methoxycoumarin has been used:
- as derivatization reagent in determination of 5-fluorouracil (5-FU) in human plasma by HPLC-tandem mass spectrometry
- as derivatization reagent in fluorescence detection of sodium monofluoroacetate (MFA-Na) in biological samples by HPLC
- in the synthesis of new caged derivatives of hydrolysis-resistant 8-bromoadenosine cyclic 3′,5′-monophosphate (8-Br-cAMP) and 8-bromoguanosine cyclic 3′,5′-monophosphate (8-Br-cGMP)
- in TLC and HPLC separation and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B₂
Verwenden
4-Bromomethyl-7-methoxycoumarin can be used as fluorescent label for fatty acids. For derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.
läuterung methode
The coumarin crystallises from boiling AcOH; the crystals are washed with AcOH, EtOH and dried in a vacuum; 1HNMR (TFA) 3.97s, 4.57s, 6.62s, 6.92-7.19m and 7.80d. [Secrist et al. Biochem Biophys Res Commun 45 1262 1971, Dünges Anal Chem 49 442 1977, Beilstein 18 III/IV 348.]

4-Bromomethyl-7-methoxycoumarin Upstream-Materialien And Downstream Produkte

4-Brommethyl-7-methoxycumarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

35231-44-8, 4-Bromomethyl-7-methoxycoumarin Verwandte Suche:

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