Dehydrocorydaline

Bezeichnung:Dehydrocorydaline

Englisch Name:Dehydrocorydaline

CBNumberCB61178432

SummenformelC22H24NO4

Molgewicht0

Dehydrocorydaline physikalisch-chemischer Eigenschaften

Schmelzpunkt	170-173℃
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Aggregatzustand	Cryst.
Stabilität	Hygroscopic

Gefahreninformationscode (GHS)

Chemische Eigenschaften
Yellow needle crystal powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Corydalis Corydalis, Yuanhu.
Verwenden
Dehydrocordine has analgesic and sedative effects. It was used for content determination/identification/pharmacological experiments, etc.
Definition
ChEBI: Dehydrocorydaline is an alkaloid.
Biologische Aktivität
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It can enhance p38 MAPK activation and has anti-inflammatory and anti-cancer effects. Also Dehydrocorydaline has potent antimalarial effects and low cytotoxicity (cell viability > 90%), P. falciparum 3D7 strain (IC50=38 nM).
in vitro

Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline.
Dehydrocorydaline (0-200 μM) dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
Dehydrocorydaline (0-200 μM) induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9.
in vivo

Dehydrocorydaline manifests a low acute toxicity with an LD ₅₀ of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection. < /p>
target

Bcl-2

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Bax

Caspase-7

Caspase-8

PARP