1,2,3-Trihydroxybenzol

Bezeichnung:1,2,3-Trihydroxybenzol

CAS-Nr87-66-1

Englisch Name:Pyrogallol

CBNumberCB6107909

SummenformelC6H6O3

Molgewicht126.11

MOL-Datei87-66-1.mol

Synonyma

Pyrogallol

1,2,3-Trihydroxybenzol

1,2,3-Benzoltriol

1,2,3-Trihydroxybenzol physikalisch-chemischer Eigenschaften

Schmelzpunkt	43-47 °C(lit.)
Siedepunkt	309 °C
Dichte	1.112 g/mL at 25 °C(lit.)
Dampfdichte	4.4 (vs air)
Dampfdruck	10 mm Hg ( 167.7 °C)
Brechungsindex	n20/D 1.387
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	water: soluble
Aggregatzustand	Very Fine Crystalline Powder
pka	pK1:9.03(0);pK2:11.63(+1) (25°C)
Farbe	White
PH	4-5 (50g/l, H2O, 20℃)
Wasserlöslichkeit	400 g/L (25 ºC)
Sensitive	Light Sensitive
Merck	14,8000
BRN	907431
Stabilität	Stable, but decolourises in light. Combustible. Incompatible with strong oxidising agents, alkalies, metal oxides, ammonia, antipyrine, phenol, iodine, lime water, menthol, potassium permanganate, strong bases.
InChIKey	WQGWDDDVZFFDIG-UHFFFAOYSA-N
LogP	-0.47
CAS Datenbank	87-66-1(CAS DataBase Reference)
NIST chemische Informationen	1,2,3-Benzenetriol(87-66-1)
EPA chemische Informationen	Pyrogallol (87-66-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-52/53-68-40-36/38
S-Sätze:	22-24/25-61-36/37-26
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	UX2800000
F	8
TSCA	Yes
HS Code	2907 29 00
HazardClass	6.1
PackingGroup	III
Giftige Stoffe Daten	87-66-1(Hazardous Substances Data)
Toxizität	LD50 orally in rabbits: 1.6 g/kg (Dollahite)

Gefahreninformationscode (GHS)

Pyrogallol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSER FESTSTOFF IN VERSCHIEDENEN FORMEN, VERFäRBT SICH GRAU BEI KONTAKT MIT LICHT UND LUFT.
CHEMISCHE GEFAHREN
Schwache Säure in wässriger Lösung. Reagiert mit Oxidationsmitteln und Basen.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Der Stoff ist reizend auf die Augen und die Atemwege und schwach reizend auf die Haut
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel. NICHT in die Umwelt gelangen lassen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen.
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R68:Irreversibler Schaden möglich.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Pyrogallol is a natural oxidant that can generate superoxide (O₂^-) in alkaline solutions through autoxidation to a semiquinone radical. Importantly, the semiquinone radical can react with O₂^- in an acidic environment to produce a quinone and H₂O₂. Pyrogallol autoxidation is used in superoxide dismutase activity assays. It can also be used in assays to assess antioxidant capacity. Pyrogallol is used in some biological systems as an O₂^- scavenger. In other biological systems, it is used as an O₂^- generator. Pyrogallol effectively scavenges DPPH radical and ABTS⁺ in vitro. Pyrogallol is a product of tannin degradation to gallic acid by ruminant microbes and has hepatotoxic and nephrotoxic effects in vivo.
Chemische Eigenschaften
white crystalline solid
Chemische Eigenschaften
White or nearly white needle- or leaf-shaped crystals or crystalline powder.Pyrogallol is practically odorless.
Verwenden
Pyrogallol is used in the manufacture of various dyes; in dyeing furs, hairs, and feathers; for staining leather; in engraving;as a developer in photography; and as an analytical reagent..
Verwenden
Complexing agent; reducing agent; alkaline solution indicator for gaseous oxygen.
Verwenden

Pyrogallol possesses importance as a spectrophotometric reagent in the determination of niobium and tantalum. The absorptions of niobium and tantalum complexes are usually measured at 340 and 335 nm, respectively. The niobium complex is formed in slightly acidic medium, and the tantalum complex in strongly acidic medium (4 N HC1). The absorption spectra are pH-dependen.
Vorbereitung Methode
Pyrogallol is prepared by heating dried gallic acid at about 200°C with the loss of carbon dioxide or by the chlorination of cyclohexanol to tetrachlorocyclohexanone, followed by hydrolysis.
Definition
ChEBI: A benzenetriol carrying hydroxy groups at positions 1, 2 and 3.
Allgemeine Beschreibung
Odorless white to gray solid. Sinks and mixes with water.
Air & Water Reaktionen
Turns gray on exposure to light or air. Water soluble.
Reaktivität anzeigen
Pyrogallol is a strong reducing agent. Reacts with alkalis, NH3, antipyrine, camphor, phenol, iron and lead salts, iodine, lime water, menthol and KMnO4.
Hazard
Toxic by ingestion and skin absorption.
Health Hazard
Inhalation of dust causes irritation of nose and throat. Ingestion may cause severe gastrointestinal irritation, convulsions, circulatory collapse, and death. Contact with eyes causes irritation. Skin contact can cause local discoloration, irritation, eczema, and death; repeated contact can cause sensitization.
Health Hazard
The toxic symptoms are similar to those of phenol. It can enter the body by absorption through skin and ingestion. The poisoning effects are nausea, vomiting, gastritis, hemolysis, methemoglobinemia, kidney and liver damage, convulsions, and congestion of lungs. High doses can cause death. Ingestion of 2–3 g of solid can be fatal to humans. The LD50 values varied widely in species. The oral LD50 value in mice is about 300 mg/kg.
Brandgefahr
Pyrogallol is probably combustible.
Kontakt-Allergie
Pyrogallol belongs to the phenols group. It is an old photograph developer and a low sensitizer in hair dyes.
Biochem/physiol Actions
Pyrogallol also referred to as 1,2,3-trihydroxybenzene inhibits the response to nitric oxide (NO) in the rat anococcygeus muscle.
Sicherheitsprofil
Human poison by ingestion and subcutaneous routes. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. 1 198 PPRSOO PYROSULFURYL CHLORIDE Readdy absorbed through the skin. Human systemic effects by ingestion: convulsions, dyspnea, gastrointestinal effects. A severe skin and eye irritant. Incompatible with alkalies, NH3, antipyrine, phenol, iron and lead salts, iodine, KMn04. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a topical antibacterial agent, as an intermediate, hair dye component, and analytical reagent.
Carcinogenicity
Pyrogallol was not carcinogenic in mouse and rabbit chronic dermal studies. Mice were treated twice weekly with pyrogallol in acetone (50%) on the shaved flank for life. There was no increase in dermal or systemic tumors. A similar study in rabbits also revealed no skin tumors, although positive controls showed an increase in tumors in both mice and rabbits.
Pyrogallol was considered to be cocarcinogenic when administered dermally three times a week together with the skin carcinogen benzo[a]pyrene for 440 days; pyrogallol administered alone caused no increase in skin tumors.

Pyrogallol Upstream-Materialien And Downstream Produkte

1,2,3-Trihydroxybenzol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

87-66-1, Pyrogallol Verwandte Suche:

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