REVERSE T3

Bezeichnung:REVERSE T3

CAS-Nr5817-39-0

Englisch Name:REVERSE T3

CBNumberCB5221268

SummenformelC15H12I3NO4

Molgewicht650.97

MOL-Datei5817-39-0.mol

REVERSE T3 physikalisch-chemischer Eigenschaften

Schmelzpunkt	234-238 °C(lit.)
Siedepunkt	534.6±50.0 °C(Predicted)
Dichte	2.387±0.06 g/cm3(Predicted)
Flammpunkt	9℃
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	powder
pka	2.17±0.20(Predicted)
Farbe	Pale Beige to Brown
Stabilität	Light Sensitive
InChI	InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey	HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	36/37/38-20/21/22-39/23/24/25-23/24/25-11
S-Sätze:	36-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	AY6750000
F	8
HS Code	29379000

Gefahreninformationscode (GHS)

REVERSE T3 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Beige Powder
Verwenden
Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.
Verwenden
One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
Definition
ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.
Biologische Aktivität
3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].
Einzelnachweise
[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.

REVERSE T3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5817-39-0, REVERSE T3 Verwandte Suche:

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