Bumetrizol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

UV Absorber 326 Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  Pale Yellow Solid

• Originator

  Bumetrizole,Onbio Inc.

• Verwenden

  UV-326 can potentially be used as a UV light filter in cosmetics and sunscreens. It may also be used as a corrosion inhibitor for the protection of building materials and automobiles.

• Verwenden

  Bumetrizole is an intermediate reactant in the synthesis of UV light absorbers for polyester fibers.

• Manufacturing Process

  To a 2000 ml 3-necked, round-bottomed flask equipped with an agitator, reflux condenser, nitrogen inlet and thermometer were charged 140.5 g of 2'- hydroxy-3'-t-butyl-5'-methyl-5-chloro-2-nitroazobenzene, 119 g of isopropanol and 80 g of Amsco mineral spirits. A stream of nitrogen was introduced over the surface of the contents of the flask and the nitrogen atmosphere was then maintained throughout the remainder of the reduction process. 13.7 g of 50% aqueous sodium hydroxide solution and 222 g of water were added and the temperature of the contents of the flask were adjusted to 55°C. The ratio of the moles of alkali to moles of o-nitroazobenzene intermediate used was is 0.848/1. 104 g of zinc dust was added in 5 portions over a 2 hours period with the temperature of the flask being held at 55-60°C with some slight external cooling. The total concentration of iron impurities from all reactants less than 150 ppm based on zinc used. After all the zinc was added, the temperature was raised to 60°C and held at this temperature until a spot test indicated no more o-nitroazobenzene intermediate was present. The temperature was then raised to 65°C and held there for 4 to 5 hours or until TLC analysis indicated that no more of the N-oxy-intermediate was present. 62.6 g of anhydrous sodium sulfate and 35.6 g of water were then added, the batch was heated to 70°C and stirred for 15 min. The material was then allowed to stand and separate into three liquid phases plus unreacted zinc dust. The top two layers containing the desired product were transferred to another flask. The remaining aqueous zinc slurry was washed at 65-70°C with three successive 16 g portions of Amsco mineral spirits: isopropanol 50:50. The combined product layers and wash liquids were then washed once at 70°C with an aqueous hydrochloric acid solution made from 130 g of water and 40 g of 32% hydrochloric acid to remove cleavage amine by-products. A second and third wash followed at 70°C with aqueous hydrochloric acid solutions made each from 65 g of water and 20 g of 32% hydrochloric acid. The last wash was essentially colorless. 14 g of 32% hydrochloric acid and 220 g of isopropanol were added to the solution of the product. The batch was allowed to crystallize slowly. The solid product form was filtered and washed with isopropanol at 0°C to give 110 g of 5-chloro-2-(2-hydroxy-3-t-butyl-5- methylphenyl)-2H-benzotriazole with a melting point of 140-141°C.

• Therapeutic Function

  Sunscreen agent

• Allgemeine Beschreibung

  2-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)-4-methylphenol (UV-326) is a benzotriazole based UV absorber that can be used in the photostabilization of industrial materials. It can absorb the harmful UV radiation for the wavelength of about 290 nm.

• Flammability and Explosibility

  Not classified

UV Absorber 326 Upstream-Materialien And Downstream Produkte

Bumetrizol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(404)Suppliers

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