cannabigerol

Bezeichnung:cannabigerol

CAS-Nr25654-31-3

Englisch Name:cannabigerol

CBNumberCB41304730

SummenformelC21H32O2

Molgewicht316.48

MOL-Datei25654-31-3.mol

cannabigerol physikalisch-chemischer Eigenschaften

Schmelzpunkt	49-50 °C
Siedepunkt	470.4±40.0 °C(Predicted)
Dichte	0.987±0.06 g/cm3(Predicted)
Flammpunkt	9℃
storage temp.	-20°C
Löslichkeit	Soluble to 100 mM in ethanol and to 100 mM in DMSO
Aggregatzustand	White to off-white powder.
pka	9.71±0.40(Predicted)
InChI	InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+
InChIKey	QXACEHWTBCFNSA-SFQUDFHCSA-N
SMILES	C1(O)=CC(CCCCC)=CC(O)=C1C/C=C(\C)/CC/C=C(/C)\C
LogP	7.470 (est)

Sicherheit

RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
HS Code	9999999999

Gefahreninformationscode (GHS)

cannabigerol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Cannabigerol (CRM) (Item No. 20164) is a certified reference material categorized as a phytocannabinoid. This product is intended for research and forensic applications.
Verwenden
Cannabigerol is a partial agonist of CB2 and CB1 receptors (Ki values are 337 and 440 nM respectively). Cannabigerol also exhibits α2-adrenoceptor agonist activity (EC50 = 0.2 nM in mouse brain membra nes).
Definition
ChEBI: A natural product found in Cannabis sativa and Helichrysum species.
benefits
Cannabigerol (CBG) works to fight inflammation, pain, nausea and works to slow the proliferation of cancer cells. Research has shown it also significantly reduces intraocular eye pressure caused by glaucoma. Strains high in CBG will be beneficial treating conditions such as inflammatory bowel disease, Crohn's disease, and cancer.
Allgemeine Beschreibung
A non-psychoactive cannabinoid found in Cannabis, Cannabigerol (CBG) reportedly has efficacy for medical conditions such as glaucoma and inflammatory bowel disease. This Certified Spiking Solution^? is suitable for cannabigerol testing methods by HPLC, GC/MS or LC-MS/MS for forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. Cerilliant solution Certified Reference Materials (CRMs) of cannabinoids are supplied in a convenient, quantitative, US DEA-exempt solution format and with TK#s for Canadian customers.
Mechanism of action
Cannabigerol shares a similar mechanism of action with the cannabinoid cannabidiol, since it binds itself weakly to CB1R and CB2R and, in addition to blocking CB1R, antagonizes 5-HT1A receptor, activates alpha (2) adrenoceptors, and is a modulator of endocannabinoid signaling. CBG acts as a strong α2-adrenoceptor agonist (EC50?=?0.2?nM), while it is only a moderate 5-HT1AR competitive antagonist, and at high concentrations (10?μM), it antagonizes [35S] guanosine 5′-O-[gamma-thio]triphosphate (GTPγS) binding in mouse brain membranes stimulated with AEA or CP-55940[1].
target
TRPV | 5-HT Receptor | ROS | NOS | PPAR | IGF-1R | Antifection
Lager
Store at -20°C
Einzelnachweise
[1] Fabrizio Calapai. “Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives.” Evidence-based Complementary and Alternative Medicine (2022): 3336516.

cannabigerol Upstream-Materialien And Downstream Produkte

cannabigerol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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