3,4-(Methylendioxy)phenol

Bezeichnung:3,4-(Methylendioxy)phenol

CAS-Nr533-31-3

Englisch Name:Sesamol

CBNumberCB2413594

SummenformelC7H6O3

Molgewicht138.12

MOL-Datei533-31-3.mol

Synonyma

3,4-(Methylendioxy)phenol

3,4-(Methylendioxy)phenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	62-65 °C (lit.)
Siedepunkt	113-116°C 2mm
Dichte	1.2112 (rough estimate)
Brechungsindex	1.4850 (estimate)
Flammpunkt	113-116°C/2mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Chloroform, Methanol
Aggregatzustand	crystalline
pka	10.08±0.20(Predicted)
Farbe	off-white to tan
Wasserlöslichkeit	slightly soluble
Sensitive	Light Sensitive
BRN	127405
InChIKey	LUSZGTFNYDARNI-UHFFFAOYSA-N
LogP	1.253 (est)
CAS Datenbank	533-31-3(CAS DataBase Reference)
NIST chemische Informationen	1,3-Benzodioxol-5-ol(533-31-3)
EPA chemische Informationen	Sesamol (533-31-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	SM0890000
Hazard Note	Irritant
TSCA	Yes
HS Code	29329970
Giftige Stoffe Daten	533-31-3(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Sesamol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
off-white to beige crystalline powder
Verwenden
Sesamol (Paroxetine Anhydrous EP Impurity B) is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).
Definition
ChEBI: Sesamol is a member of benzodioxoles.
benefits
Sesamol, 5-hydroxy-1,3-benzodioxole or 3,4-methylene-dioxyphenol, is a water-soluble phenolic lignan isolated from roasted sesame seeds and processed sesame oil. Various studies investigated the anti-cancer therapeutic potential of sesamol, and the literature provided reveals compelling evidence that sesamol acts as a metabolic regulator and possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 3085, 1978 DOI: 10.1016/S0040-4039(01)94947-0
Allgemeine Beschreibung
Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10)
Biologische Aktivität
Sesamol has a wide range of biological actions including inhibition of lipid peroxidation and enhancement of radical scavenging, upregulation of antioxidant enzymes, suppression of TNFα 80 and IL-1β expression, inhibition of NF-κB 81 signaling, suppression of LOX-1 82 and 5-LOX activity, induction of 83 apoptosis, arresting cell growth at different phases of the cell cycle; and modulation of caspase-3, p53, Bax, and Bcl2 expression[3].

Sesamol Upstream-Materialien And Downstream Produkte

3,4-(Methylendioxy)phenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

533-31-3, Sesamol Verwandte Suche:

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